Impact of Head-of-Bed Posture on Brain Oxygenation in Patients with Acute Brain Injury: A Prospective Cohort Study

• Published in: Neurocritical care Vol. 35; no. 3; pp. 662 - 668
• Main Authors: Burnol, Laetitia, Payen, Jean-Francois, Francony, Gilles, Skaare, Kristina, Manet, Romain, Morel, Jérôme, Bosson, Jean-Luc, Gergele, Laurent
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2021; Springer Nature B.V
• Subjects: Brain; Brain Injuries - therapy; Cerebrovascular Circulation - physiology; Cohort analysis; Critical Care Medicine; Ethics; Flow velocity; Humans; Intensive; Internal Medicine; Intracranial Pressure - physiology; Medicine; Medicine & Public Health; Neurology; Neurosurgery; Original Work; Patients; Posture - physiology; Prospective Studies; Review boards; Traumatic brain injury; Ventilators; France; Upright; Acute brain injury; Intracranial pressure; Cerebral circulation
• ISSN: 1541-6933; 1556-0961
• DOI: 10.1007/s12028-021-01240-1

Background Therapeutic head positioning plays a role in the management of patients with acute brain injury. Although intracranial pressure (ICP) is typically lower in an upright posture than in a flat position, limited data exist concerning the effect of upright positioning on brain oxygenation and circulation. We sought to determine the impact of supine (0°) and semirecumbent (15° and 30°) postures on ICP, brain oxygenation, and brain circulation. Methods An observational cohort study was conducted between February 2012 and September 2015. Twenty-three patients with severe acute brain injury were successively observed at head elevations of 30°, 15°, and 0°. Postural-induced changes in ICP, cerebral perfusion pressure, brain tissue oxygenation pressure, and transcranial Doppler findings were simultaneously measured during three repeated experiments: 24 h after admission to the intensive care unit (exp1), 24 h later (exp2), and 96 h later (exp3). Cerebral perfusion pressure, arterial blood gases, hemoglobin content, and body temperature remained unchanged during the three experiments. Results Using linear random-slope mixed models, we found that during the early phase of acute brain injury (exp1), lowering the head posture from 30° to 15°, and then to 0°, was associated with a gradual mean ICP increase of 2.6 mm Hg (1.4–3.7 mm Hg; P  < 0.001); and from 30° to 0°, an increase of 7.4 mm Hg (6.3–8.6 mm Hg; P  < 0.001). Furthermore, brain tissue oxygenation pressure and mean blood flow velocity improved when the head posture was lowered from 30° to 0° by 1.2 mm Hg (0.2–2.3 mm Hg) and 4.1 cm/s (0.0–8.2 cm/s), respectively (both P  < 0.05). Conclusions Changing the positioning of stable patients with acute brain injury resulted in opposite changes of ICP versus brain oxygenation and circulation. This information supports the concept of an individualized approach to head positioning that is based on the multimodal monitoring of brain parameters.