Evaluating aeration and stirring effects to improve itaconic acid production from glucose using Aspergillus terreus

The effects of the bioreactor conditions, in particular the mode and intensity of aeration and mixing were studied on itaconic acid (IA) fermentation efficiency by Aspergillus terreus strain from glucose substrate. IA was produced in batch system by systematically varying the oxygen content of the a...

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Bibliographic Details
Published inBiotechnology letters Vol. 41; no. 12; pp. 1383 - 1389
Main Authors Nemestóthy, Nándor, Bakonyi, Péter, Komáromy, Péter, Bélafi-Bakó, Katalin
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.12.2019
Springer Nature B.V
Subjects
Acid production
Aeration
Applied Microbiology
Aspergillus - growth & development
Aspergillus - metabolism
Aspergillus terreus
Biochemistry
Biomedical and Life Sciences
Bioreactors
Bioreactors - microbiology
Biotechnology
Fermentation
Glucose
Glucose - metabolism
Itaconic acid
Life Sciences
Microbiology
Original Research Paper
Oxygen - metabolism
Oxygen content
Stirring
Substrates
Succinates - metabolism
Aeration
Itaconic acid fermentation
Process enhancement
Kinetic modeling
Stirring
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Summary:The effects of the bioreactor conditions, in particular the mode and intensity of aeration and mixing were studied on itaconic acid (IA) fermentation efficiency by Aspergillus terreus strain from glucose substrate. IA was produced in batch system by systematically varying the oxygen content of the aeration gas (from 21 to 31.5 vol% O 2 ) and the stirring rate (from 150 to 600 rpm). The data were analyzed kinetically to characterize the behavior of the process, and besides, the performances were evaluated comparatively with the literature. It turned out that the operation of the bioreactor with either the higher inlet O 2 concentration (31.5 vol% O 2 ) or faster stirring (600 rpm) could enhance biological IA generation the most, resulting in yield and volumetric productivity of 0.31 g IA/g glucose and 0.32 g IA/g glucose and 3.15 g IA/L day and 4.26 g IA/L day, respectively. Overall, the significance of fermentation settings was shown in this work regarding IA production catalyzed by A. terreus and notable advances could be realized by adjusting the aeration and stirring towards an optimal combination. Graphic abstract
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ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-019-02742-x