Neutrophil Extracellular Traps (NETs): A New Therapeutic Target for Neuroinflammation and Microthrombosis After Subarachnoid Hemorrhage?

Neutrophil extracellular traps (NETs) play a major role in intrinsic immunity by limiting and killing pathogens. Recently, a series of studies have confirmed that NETs are closely associated with vascular injury and microthrombosis. Furthermore, NETs play an important role in neuroinflammation after...

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Published inTranslational stroke research Vol. 14; no. 4; pp. 443 - 445
Main Authors Zhou, Jiru, Guo, Peiwen, Hao, Xiaoke, Sun, Xiaochuan, Feng, Hua, Chen, Zhi
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2023
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Blood
Blood platelets
Brain research
Cardiology
Clinical trials
Comment
COVID-19
Extracellular Traps - physiology
Hematoma
Hemorrhage
Humans
Ischemia
Magnetic resonance imaging
Neuroinflammatory Diseases
Neurology
Neurosciences
Neurosurgery
Neutrophils
Stroke
Subarachnoid Hemorrhage - complications
Thrombosis
Thrombosis - drug therapy
Thrombosis - etiology
Traumatic brain injury
Vascular Surgery
Neuroinflammation
Subarachnoid hemorrhage
Neutrophil extracellular traps
Microthrombosis
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Summary:Neutrophil extracellular traps (NETs) play a major role in intrinsic immunity by limiting and killing pathogens. Recently, a series of studies have confirmed that NETs are closely associated with vascular injury and microthrombosis. Furthermore, NETs play an important role in neuroinflammation after ischemic and hemorrhagic stroke. Neuroinflammation and microthrombosis after subarachnoid hemorrhage are key pathophysiological processes associated with poor prognosis, but their crucial formation mechanisms and interventions remain to be elucidated. Could NETs, as an emerging and important pathogenesis, be a new therapeutic target after subarachnoid hemorrhage?
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
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ObjectType-Correspondence-1
ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-022-01039-y