Actin coats and rings promote regulated exocytosis

It is well known that actin can associate with intracellular membranes to drive endocytosis and the rocketing motion of bacteria, virions and some organelles and to regulate synaptic vesicle plasticity. Actin also has been extensively reported to be involved at several steps of exocytosis; however,...

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Bibliographic Details
Published inTrends in cell biology Vol. 22; no. 6; pp. 329 - 337
Main Authors Nightingale, Thomas D, Cutler, Daniel F, Cramer, Louise P
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2012
Subjects
actin
Actins - metabolism
Animals
Exocytosis
granules
Humans
myosin II
Pathology
Protein Binding
secretion
Transport Vesicles - metabolism
actin
exocytosis
secretion
myosin II
granules
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Summary:It is well known that actin can associate with intracellular membranes to drive endocytosis and the rocketing motion of bacteria, virions and some organelles and to regulate synaptic vesicle plasticity. Actin also has been extensively reported to be involved at several steps of exocytosis; however, it has typically been described as functioning either within the actin cortex or by providing actin tracks for organelle transport. Increasingly, actin filament coats or rings have been directly localized on the surface of the exocytic organelle. Here, we suggest a common mechanism for actin-based regulation of large secretory granules whereby organelle-associated actomyosin II contraction either directly expels secretory content or stabilizes the exocytosing organelle.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2012.03.003