Mathematical analysis for internal filtration of convection-enhanced high-flux hemodialyzer

• Published in: Computer methods and programs in biomedicine Vol. 108; no. 1; pp. 68 - 79
• Main Authors: Lee, Jung Chan, Lee, Kyungsoo, Kim, Hee Chan
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 01.10.2012; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Backfiltration; Biological and medical sciences; Convection; Emergency and intensive care: renal failure. Dialysis management; Filtration - methods; Fundamental and applied biological sciences. Psychology; Hemodialysis; Hemodialyzer; Hemodynamics. Rheology; High-flux; Intensive care medicine; Internal filtration; Internal Medicine; Medical sciences; Other; Renal Dialysis - instrumentation; Ultrafiltration; Vertebrates: cardiovascular system; Ultrafiltration; Internal filtration; Hemodialysis; High-flux; Hemodialyzer; Backfiltration; Convection; Filtration; Iterative method; Internal model principle; Experimental study; Modeling; Membrane separation; Circulatory system; Hemodynamics
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/j.cmpb.2012.01.001

Highlights ► Convection mechanism inside convection-enhanced high-flux hemodialyzer is presented. ► Mathematical model is employed and numerical analysis is performed to estimate internal filtration rates. ► Two-stage nested iterative procedure is used to solve governing equations. ► Internal filtration volume that occurred by forward filtration and backfiltration is two times higher in convection-enhanced high-flux hemodialyzer than in conventional high-flux hemodialyzer.