Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of Americans each year with significant population health impact. Despite the existence of a large body of information on the subject, the molecular under...
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Published in | Molecular neurobiology Vol. 58; no. 6; pp. 2836 - 2850 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.06.2021
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of Americans each year with significant population health impact. Despite the existence of a large body of information on the subject, the molecular underpinnings of orofacial pain remain elusive. Two decades of research has identified that transient receptor potential (TRP) ion channels play a crucial role in pathological pain. A number of TRP ion channels are clearly expressed in the trigeminal sensory system and have critical functions in the transduction and pathogenesis of orofacial pain. Although there are many similarities, the orofacial sensory system shows some distinct peripheral and central pain processing and different sensitivities from the spinal sensory system. Relative to the extensive review on TRPs in spinally-mediated pain, the summary of TRPs in trigeminally-mediated pain has not been well-documented. This review focuses on the current experimental evidence involving TRP ion channels, particularly TRPV1, TRPA1, TRPV4, and TRPM8 in orofacial pain, and discusses their possible cellular and molecular mechanisms. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 YHL and YC conceived the original idea and designed the outlines of the study. YHL, AS, QJZ, PW, and YC performed the literature review and wrote the draft of the manuscript. YHL and YC prepared the figures and tables for the manuscript. All authors have read and agreed to the final version of the manuscript. Author contributions |
ISSN: | 0893-7648 1559-1182 |
DOI: | 10.1007/s12035-021-02284-2 |