Frontal and parietal EEG alpha asymmetry: a large-scale investigation of short-term reliability on distinct EEG systems

• Published in: Brain Structure and Function Vol. 227; no. 2; pp. 725 - 740
• Main Authors: Metzen, Dorothea, Genç, Erhan, Getzmann, Stephan, Larra, Mauro F., Wascher, Edmund, Ocklenburg, Sebastian
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2022; Springer Nature B.V
• Subjects: Asymmetry; Biomedical and Life Sciences; Biomedicine; Cell Biology; EEG; Electrodes; Electroencephalography; Eye; Frontal Lobe; Hemispheric laterality; Humans; Investigations; Nervous system; Neurology; Neurosciences; Original; Original Article; Reproducibility of Results; Handedness; Electroencephalogram (EEG); Reliability; Frontal alpha asymmetry; Parietal alpha asymmetry
• ISSN: 1863-2653; 1863-2661; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-021-02399-1

EEG resting-state alpha asymmetry is one of the most widely investigated forms of functional hemispheric asymmetries in both basic and clinical neuroscience. However, studies yield inconsistent results. One crucial prerequisite to obtain reproducible results is the reliability of the index of interest. There is a body of research suggesting a moderate-to-good reliability of EEG resting-state alpha asymmetry, but unfortunately sample sizes in these studies are typically small. This study presents the first large-scale short-term reliability study of frontal and parietal EEG resting-state alpha asymmetry. We used the Dortmund Vital Study data set containing 370 participants. In each participant, EEG resting state was recorded eight times, twice with their eyes opened, twice with their eyes-closed, each on two different EEG systems. We found good reliability of EEG alpha power and alpha asymmetry on both systems for electrode pairs. We also found that alpha power asymmetry reliability is higher in the eyes-closed condition than in the eyes-open condition. The frontomedial electrode pair showed weaker reliability than the frontolateral and parietal electrode pairs. Interestingly, we found no population-level alpha asymmetry in frontal electrodes, one of the most investigated electrode sites in alpha asymmetry research. In conclusion, our results suggest that while EEG alpha asymmetry is an overall reliable measure, frontal alpha asymmetry should be assessed using multiple electrode pairs.