Classification and Pathology of Lung Cancer

Advancement in the understanding of lung tumor biology enables continued refinement of lung cancer classification, reflected in the recently introduced 2015 World Health Organization classification of lung cancer. In small biopsy or cytology specimens, special emphasis is placed on separating adenoc...

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Bibliographic Details
Published inSurgical oncology clinics of North America Vol. 25; no. 3; p. 447
Main Author Zheng, Min
Format Journal Article
LanguageEnglish
Published United States 01.07.2016
Subjects
Carcinoid Tumor - classification
Carcinoid Tumor - pathology
Carcinoma, Neuroendocrine - classification
Carcinoma, Neuroendocrine - pathology
Humans
Lung Neoplasms - classification
Lung Neoplasms - pathology
Neuroendocrine Tumors - classification
Neuroendocrine Tumors - pathology
Small Cell Lung Carcinoma - classification
Small Cell Lung Carcinoma - pathology
Immunohistochemistry
Pathology
Molecular testing
Lung cancer
Classification
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Summary:Advancement in the understanding of lung tumor biology enables continued refinement of lung cancer classification, reflected in the recently introduced 2015 World Health Organization classification of lung cancer. In small biopsy or cytology specimens, special emphasis is placed on separating adenocarcinomas from the other lung cancers to effectively select tumors for targeted molecular testing. In resection specimens, adenocarcinomas are further classified based on architectural pattern to delineate tissue types of prognostic significance. Neuroendocrine tumors are divided into typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma based on a combination of features, especially tumor cell proliferation rate.
ISSN:1558-5042
DOI:10.1016/j.soc.2016.02.003