Profiling of Differentially Expressed Genes in Human Stem Cells by cDNA Microarray

• Published in: Molecules and cells Vol. 21; no. 3; pp. 343 - 355
• Main Authors: Kim, C.G. (Hanyang University, Seoul, Republic of Korea), E-mail: cgkim@hanyang.ac.kr, Lee, J.J. (Hanyang University, Seoul, Republic of Korea), Jung, D.Y. (Hanyang University, Seoul, Republic of Korea), Jeon, J.S. (Hanyang University, Seoul, Republic of Korea), Heo, H.S. (Hanyang University, Seoul, Republic of Korea), Kang, H.C. (Hanyang University, Seoul, Republic of Korea), Shin, J.H. (Hanyang University, Seoul, Republic of Korea), Cho, Y.S. (Hanyang University, Seoul, Republic of Korea), Cha, K.J. (Hanyang University, Seoul, Republic of Korea), Kim, C.G. (Konkuk University, Chungju, Republic of Korea), Do, B.R. (HuRim Bio Cell Inc., Seoul, Republic of Korea), Kim, K.S. (CoreStem Company, Changwon, Republic of Korea), Kim, H.S. (FCB PharMiCell Inc., Sungnam, Republic of Korea)
• Format: Journal Article
• Language: English
• Published: United States 한국분자세포생물학회 30.06.2006
• Subjects: Adult; Bone Marrow Cells - metabolism; cDNA Microarray; Cell Differentiation; Embryo, Mammalian - cytology; Embryo, Mammalian - metabolism; Expression Profiling; GENE; Gene Expression Profiling; Gene Expression Regulation; GENES; Hematopoietic Stem Cells - metabolism; Human CD133+ Hematopoietic Stem/Progenitor Cells; Human CD34+ Hematopoietic Stem/Progenitor Cells; Human Embryonic Stem Cells; Human Mesenchymal Stem Cells; Humans; Mesenchymal Stem Cells - metabolism; Oligonucleotide Array Sequence Analysis; Stem Cell Signature; 생물학
• ISSN: 1016-8478; 0219-1032
• DOI: 10.1016/s1016-8478(23)12862-7

Stem cells are unique cell populations with the ability to undergo both self-renewal and differentiation, although a wide variety of adult stem cells as well as embryonic stem cells have been identified and stem cell plasticity has recently been reported. To identify genes implicated in the control of the stem cell state as well as the characteristics of each stem cell line, we analyzed the expression profiles of genes in human embryonic, hematopoietic (CD34+ and CD133+), and mesenchymal stem cells using cDNA microarrays, and identified genes that were differentially expressed in specific stem cell populations.