Diagnosis and Management of Malignant Salivary Gland Tumors of the Parotid Gland

Malignant parotid tumors are heterogeneous and diverse. Accurate diagnosis requires a pathologist familiar with the various histologic subtypes, immunohistochemistry stains, and common translocations. Clinical course varies according to tumor subtype, ranging from indolent, slow-growing adenoid cyst...

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Bibliographic Details
Published inOtolaryngologic clinics of North America Vol. 49; no. 2; pp. 343 - 380
Main Authors Lewis, Aaron G., MD, Tong, Tommy, MD, Maghami, Ellie, MD
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2016
Subjects
Biopsy, Fine-Needle
Carcinoma, Adenoid Cystic - pathology
Carcinoma, Adenoid Cystic - therapy
Carcinoma, Mucoepidermoid - pathology
Carcinoma, Mucoepidermoid - therapy
Chemotherapy for parotid tumors
Disease Management
Drug Therapy
Genetic translocations of parotid tumors
Humans
Immunohistochemistry
Malignant salivary cancers
Molecular diagnostics
Molecular targeted therapies
Molecular Targeted Therapy
Otolaryngology
Parotid cancer
Parotid Gland - pathology
Parotid Neoplasms - diagnosis
Parotid Neoplasms - therapy
Prognosis
Radiation therapy for parotid cancers
Radiotherapy
Reconstructive Surgical Procedures
Surgery
Surgery for parotid salivary cancer
Genetic translocations of parotid tumors
Molecular diagnostics
Malignant salivary cancers
Radiation therapy for parotid cancers
Parotid cancer
Chemotherapy for parotid tumors
Surgery for parotid salivary cancer
Molecular targeted therapies
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Summary:Malignant parotid tumors are heterogeneous and diverse. Accurate diagnosis requires a pathologist familiar with the various histologic subtypes, immunohistochemistry stains, and common translocations. Clinical course varies according to tumor subtype, ranging from indolent, slow-growing adenoid cystic carcinoma to rapidly progressive, possibly fatal, salivary ductal carcinoma. Histologic grade is important in prognosis and therapy. Surgery remains the mainstay of treatment when negative margins can be achieved. Radiation improves locoregional control of tumors with high-risk features. Chemotherapy for parotid tumors can be disappointing. Studies of new targeted therapies have not offered significant benefits.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0030-6665
1557-8259
DOI:10.1016/j.otc.2015.11.001