Diphenyl diselenide alone and in combination with itraconazole against Sporothrix schenckii s.str. and Sporothrix globosa

• Published in: Brazilian journal of microbiology Vol. 52; no. 3; pp. 1271 - 1274
• Main Authors: Poester, Vanice Rodrigues, Munhoz, Lívia Silveira, Nogueira, Cristina Wayne, Zeni, Gilson Rogério, Stevens, David A., Xavier, Melissa Orzechowski
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2021; Springer Nature B.V
• Subjects: Antifungal activity; Antifungal agents; Antifungal Agents - pharmacology; Benzene Derivatives - pharmacology; Biomedical and Life Sciences; Biotechnology and Industrial Microbiology - Short Communication; Clinical isolates; Food Microbiology; Fungicides; In vivo methods and tests; Itraconazole; Itraconazole - pharmacology; Life Sciences; Medical Microbiology; Microbial Ecology; Microbial Genetics and Genomics; Microbial Sensitivity Tests; Microbiology; Mycology; Organoselenium Compounds - pharmacology; Sporothrix - drug effects; Sporothrix globosa; Sporothrix schenckii; Antifungal activity; Sporotrichosis; Organoselenium compound; Subcutaneous mycoses
• ISSN: 1517-8382; 1678-4405
• DOI: 10.1007/s42770-021-00506-2

We evaluated the in vitro susceptibility of Sporothrix schenckii s.str. and Sporothrix globosa to diphenyl diselenide (PhSe) 2 alone and in association with itraconazole (ITZ). Eight clinical isolates were tested in microdilution and checkerboard assays. (PhSe) 2 alone inhibited all isolates in concentration ≤ 8 µg/mL and was effective in killing one S. schenckii isolate. Inhibitory and fungicidal beneficial effects in its interaction with ITZ were shown against 87.5% (7/8) and 50% (4/8) of the isolates tested, respectively. Our study demonstrates the in vitro antifungal activity of (PhSe) 2 against two pathogenic Sporothrix species, suggesting studies of in vivo applications are warranted.