Disrupted intestinal mucosal barrier mediated by alcohol consumption aggravates systemic microplastic accumulation

• Published in: Ecotoxicology and environmental safety Vol. 262; p. 115342
• Main Authors: Baek, Su-Min, Kim, Tae-Un, Lee, Young-Jin, Lee, Seoung-Woo, Yim, Jae-Hyuk, Kim, Woo Jun, Kim, Hee-Yeon, Kang, Kyung-Ku, Kim, Sung Dae, Park, Sang-Joon, Choi, Seong-Kyoon, Park, Jin-Kyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.09.2023; Elsevier
• Subjects: Alcohol; Gut–liver axis; Hepatic steatosis; Intestinal mucosal barrier; Microplastics; Intestinal mucosal barrier; Alcohol; Microplastics; Gut–liver axis; Hepatic steatosis
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2023.115342

Waste plastics are degraded into microplastics (MPs), which are easily accumulated in the human body through digestive tracts, via the food chain. Alcohol is a widely consumed chemical throughout the world with the ability to alter the intestinal barrier. For this reason, this study was aimed to investigate exact relevance between alcohol consumption and organ distributions of MPs in an ethanol feeding animal model characterized by disrupted intestinal mucosal barriers. In this study, C57BL/6 mice were separated into control, control + MP, ethanol (EtOH), and EtOH + MP groups. Mice in the EtOH group ingested a Lieber–DeCarli diet containing EtOH. Mice in the MP groups ingested 0.1 mg/kg fluorophore polymerized polystyrene microplastics via oral gavage polystyrene MPs via oral gavage. The EtOH + MP group showed higher MP accumulation in the liver than the control + MP group. The same pattern was observed in the intestines, spleen, and brain. This pattern was more prominent in the intestines, with the EtOH + MP group showing the most severe damage due to EtOH ingestion. This result suggests that the intestinal mucosa disruption caused by EtOH ingestion exacerbates MP accumulation in the organs. Moreover, hepatic steatosis was more severe in the EtOH + MP group than in the EtOH group, suggesting the secondary manifestation mediated by MP accumulation. This study reports a novel MP accumulation pattern in the body by providing novel insights into alcohol-induced gut permeability and microplastics toxicity from the perspective of gut-liver axis. [Display omitted] •Alcohol severely disintegrated tight junctions of the intestinal epithelium.•Microplastic (MP) accumulation was mainly observed in the disrupted lamina propria.•Disrupted intestinal mucosa facilitates MPs to enter the portal vein.•Increased MPs in the blood flow exacerbates MP accumulation in visceral organs.