The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

• Published in: Molecular neurobiology Vol. 60; no. 1; pp. 247 - 263
• Main Authors: Liu, Na, Lin, Miao-Miao, Wang, Yan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2023; Springer Nature B.V
• Subjects: Alzheimer's disease; Autophagy; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cell cycle; Dopamine; Enzymes; Homeostasis; Humans; Kinases; Laboratories; Literature reviews; Mutation; Neurobiology; Neurodegenerative Diseases; Neurology; Neurosciences; Pathogenesis; Proteins; Quality control; Roles; Signal transduction; Therapeutic targets; Ubiquitin; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Deubiquitinating enzymes; Ubiquitination; Neurodegenerative diseases; E3 ubiquitin ligases

Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurod...