The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurod...

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Published inMolecular neurobiology Vol. 60; no. 1; pp. 247 - 263
Main Authors Liu, Na, Lin, Miao-Miao, Wang, Yan
Format Journal Article
LanguageEnglish
Published New York Springer US 01.01.2023
Springer Nature B.V
Subjects
Alzheimer's disease
Autophagy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell cycle
Dopamine
Enzymes
Homeostasis
Humans
Kinases
Laboratories
Literature reviews
Mutation
Neurobiology
Neurodegenerative Diseases
Neurology
Neurosciences
Pathogenesis
Proteins
Quality control
Roles
Signal transduction
Therapeutic targets
Ubiquitin
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - metabolism
Ubiquitination
Deubiquitinating enzymes
Ubiquitination
Neurodegenerative diseases
E3 ubiquitin ligases
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Summary:Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.
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ISSN:0893-7648
1559-1182
1559-1182
DOI:10.1007/s12035-022-03063-3