Basic research on curcumin in cervical cancer: Progress and perspectives

• Published in: Biomedicine & pharmacotherapy Vol. 162; p. 114590
• Main Authors: Zhang, Xiaoyu, Zhu, Lin, Wang, Xuezhen, Zhang, Hairong, Wang, Lianzhong, Xia, Lei
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2023; Elsevier
• Subjects: Antineoplastic Agents - pharmacology; Cervical cancer; Curcumin; Curcumin - pharmacology; Female; Humans; Mechanism; Papillomavirus Infections; Pathway; Plants; Systematic Reviews as Topic; Uterine Cervical Neoplasms; CDKi; MDC1; HDACs; PS; CDF; Ras; DMSO; JNK; Pathway; NOD-SCID; HCFs; HIF-1α; BRCA1; CDK; AP-1; Rho A; NF-κB; Hsp70; iNOS; AIF; uPA; Plants; ER; IRE-1a; MMP-2; ROS; ATF6; MMP-9; Pgp1; DDAB; Cervical cancer; ERK; PCNA; COX-2; c-myc; BDMC; THC; EGFR; Mechanism; HPV; H2A.X; FRA-1; TGF-β; Curcumin; TrxR; PDT; MRP1; DNA-PK; MGMT; ASK1; VEGF; c-fos; AKT; PTPN13; PLGA; PBCA; Pin1; ATM; GRB2; ATR
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2023.114590

Curcumin is a polyphenolic substance extracted from plants such as Curcuma longa, Curcuma zedoaria, and radix curcumae, and it has attracted much attention because of the anti-inflammatory, antioxidant, anti-tumor, antibacterial and other multiple pharmacological effects. Cervical cancer is one of the most common malignant tumors in women. With the application of HPV (human papillomavirus) vaccine, the incidence of cervical cancer is expected to be reduced, but it remains difficult to promote the vaccine among low-income population. As a commonly used food additive, curcumin has recently been found to have a significant therapeutic effect in the treatment of cervical cancer. In recent years, numerous in vitro and in vivo studies have found that curcumin can have significant efficacy in anti-cervical cancer treatment by promoting apoptosis, inhibiting tumour cell proliferation, metastasis and invasion, inhibiting HPV and inducing autophagy in tumour cells. However, due to poor water solubility, rapid catabolism, and low bioavailability of curcumin, studies on curcumin derivatives and novel formulations are increasing. Curcumin has a wide range of mechanisms of action against cervical cancer and may become a novel antitumor drug in the future, opening up new ideas for the research of curcumin in the field of antitumor. There is a lack of systematic reviews on the mechanism of action of curcumin against cervical cancer. Therefore, this study is a review of the literature based on the mechanism of action of curcumin against cervical cancer, with a view to providing reference information for scientific and clinical practitioners.