Oxidative stress in mice treated with antileishmanial meglumine antimoniate

• Published in: Research in veterinary science Vol. 95; no. 3; pp. 1134 - 1141
• Main Authors: Bento, D.B., de Souza, B., Steckert, A.V., Dias, R.O., Leffa, D.D., Moreno, S.E., Petronilho, F., de Andrade, V.M., Dal-Pizzol, F., Romão, P.R.
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.12.2013; Elsevier Limited
• Subjects: Acids; acute effects; adverse effects; Animals; antimony; Antioxidants; Antiprotozoal Agents - adverse effects; Antiprotozoal Agents - pharmacology; Behavior; brain; Brain - drug effects; Brain Chemistry - drug effects; Brain research; Catalase; Catalase - metabolism; Cytotoxicity; Drug dosages; glutathione; Glutathione - analysis; Heart; Heart - drug effects; Kidney - chemistry; Kidney - drug effects; kidneys; Laboratory animals; Lipid Peroxidation - drug effects; Lipoperoxidation; liver; Liver - chemistry; Liver - drug effects; Meglumine - adverse effects; Meglumine - pharmacology; Meglumine antimoniate; Mice; Myocardium - chemistry; nitrogen; Organometallic Compounds - adverse effects; Organometallic Compounds - pharmacology; Oxidative stress; Oxidative Stress - drug effects; oxygen; Parasitic diseases; Protein carbonylation; Protein Carbonylation - drug effects; Rodents; Spleen; Spleen - chemistry; Spleen - drug effects; Superoxide dismutase; Superoxide Dismutase - metabolism; toxicity; Veterinary medicine; Oxidative stress; Superoxide dismutase; Protein carbonylation; Catalase; Lipoperoxidation; Meglumine antimoniate
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2013.08.004

In order to improve the understanding of the toxicity of pentavalent antimony (SbV), we investigated the acute effects of meglumine antimoniate (MA) on the oxidative stress in heart, liver, kidney, spleen and brain tissue of mice. Levels of lipoperoxidation and protein carbonylation were measured to evaluate the oxidative status, whereas superoxide dismutase/catalase activity and glutathione levels were recorded to examine the antioxidative status. We observed that MA caused significant protein carbonylation in the heart, spleen and brain tissue. Increased lipoperoxidation was found in the liver and brain tissue. An imbalance between superoxide dismutase and catalase activities could be observed in heart, liver, spleen and brain tissue. Our results suggest that MA causes oxidative stress in several vital organs of mice. This indicates that the production of highly reactive oxygen and nitrogen species induced by MA might be involved in some of its toxic adverse effects.