The Impact of Bariatric Surgery on Breast Cancer Recurrence: Case Series and Review of Literature

• Published in: Obesity surgery Vol. 30; no. 2; pp. 780 - 785
• Main Authors: Zhang, Shijia, Ikramuddin, Sayeed, Beckwith, Heather C., Sheka, Adam C., Wirth, Keith M., Blaes, Anne H.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2020; Springer Nature B.V
• Subjects: Adult; Bariatric Surgery - methods; Bariatric Surgery - statistics & numerical data; Breast cancer; Breast Neoplasms - epidemiology; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Brief Communication; Cancer therapies; Cohort Studies; Female; Gastrectomy - methods; Gastrectomy - statistics & numerical data; Gastric Bypass - methods; Gastric Bypass - statistics & numerical data; Gastrointestinal surgery; Humans; Laparoscopy; Laparoscopy - methods; Laparoscopy - statistics & numerical data; Mastectomy; Medical diagnosis; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Recurrence, Local - epidemiology; Obesity, Morbid - epidemiology; Obesity, Morbid - surgery; Prospective Studies; Retrospective Studies; Surgery; Weight Gain - physiology; Weight Loss - physiology; Recurrence; Breast cancer; Bariatric surgery; Weight loss
• ISSN: 0960-8923; 1708-0428
• DOI: 10.1007/s11695-019-04099-6

Background Excess body weight has been associated with worsening breast cancer survival. While bariatric surgery has been associated with less incident of breast cancer, the role that bariatric surgery plays after breast cancer diagnosis in terms of both feasibility and in preventing breast cancer recurrence is unclear. Methods We report the outcomes of 13 individuals who underwent bariatric surgery after definitive breast cancer treatment at a single institution. Results Thirteen females diagnosed with breast cancer (69.2% stage I, 23.1% stage II) at a median age of 42 years received bariatric surgery between 2001 and 2017. The median age of bariatric surgery was 52 years. Of the 13 patients, 46.2% underwent laparoscopic Roux-en-Y gastric bypass and 38.5% laparoscopic sleeve gastrectomy. The median time from breast cancer treatment to bariatric surgery was 3 years. The procedures were well tolerated. One female developed an abdominal wall hematoma. The average weight loss after 1 year and 2 years was 28.1% and 28.2%, respectively. There was a single breast cancer recurrence with a median follow-up of 11.7 years after breast cancer diagnosis and 5.3 years after bariatric surgery. Conclusions Bariatric surgery after breast cancer treatment is feasible and well tolerated. Prospective trials evaluating bariatric surgery in obese breast cancer survivors should be considered.