Cortical spectral matching and shape and volume analysis of the fetal brain pre- and post-fetal surgery for spina bifida: a retrospective study

• Published in: Neuroradiology Vol. 63; no. 10; pp. 1721 - 1734
• Main Authors: Mufti, Nada, Aertsen, Michael, Ebner, Michael, Fidon, Lucas, Patel, Premal, Rahman, Muhamad Bin Abdul, Brackenier, Yannick, Ekart, Gregor, Fernandez, Virginia, Vercauteren, Tom, Ourselin, Sebastien, Thomson, Dominic, De Catte, Luc, Demaerel, Philippe, Deprest, Jan, David, Anna L., Melbourne, Andrew
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2021; Springer Nature B.V
• Subjects: Abnormalities; Biometrics; Brain; Brain - diagnostic imaging; Brain - surgery; Central nervous system; Cerebellum; Cognition; Diameters; Fetus; Fetuses; Hindbrain; Humans; Imaging; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Meningomyelocele - diagnostic imaging; Meningomyelocele - surgery; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Occipital lobe; Paediatric Neuroradiology; Parietal lobe; Radiology; Retrospective Studies; Skull; Spina bifida; Spinal Dysraphism; Substantia alba; Surgery; Temporal lobe; Ventricle; Fetal surgery; Myelomeningocele; Shape; MRI; Volume; Cortical spectral matching
• ISSN: 0028-3940; 1432-1920; 1432-1920
• DOI: 10.1007/s00234-021-02725-8

Purpose A retrospective study was performed to study the effect of fetal surgery on brain development measured by MRI in fetuses with myelomeningocele (MMC). Methods MRI scans of 12 MMC fetuses before and after surgery were compared to 24 age-matched controls without central nervous system abnormalities. An automated super-resolution reconstruction technique generated isotropic brain volumes to mitigate 2D MRI fetal motion artefact. Unmyelinated white matter, cerebellum and ventricles were automatically segmented, and cerebral volume, shape and cortical folding were thereafter quantified. Biometric measures were calculated for cerebellar herniation level (CHL), clivus-supraocciput angle (CSO), transverse cerebellar diameter (TCD) and ventricular width (VW). Shape index (SI), a mathematical marker of gyrification, was derived. We compared cerebral volume, surface area and SI before and after MMC fetal surgery versus controls. We additionally identified any relationship between these outcomes and biometric measurements. Results MMC ventricular volume/week (mm 3 /week) increased after fetal surgery (median: 3699, interquartile range (IQR): 1651–5395) compared to controls (median: 648, IQR: 371–896); P  = 0.015. The MMC SI is higher pre-operatively in all cerebral lobes in comparison to that in controls. Change in SI/week in MMC fetuses was higher in the left temporal lobe (median: 0.039, IQR: 0.021–0.054), left parietal lobe (median: 0.032, IQR: 0.023–0.039) and right occipital lobe (median: 0.027, IQR: 0.019–0.040) versus controls ( P  = 0.002 to 0.005). Ventricular volume (mm 3 ) and VW (mm) ( r  = 0.64), cerebellar volume and TCD ( r  = 0.56) were moderately correlated. Conclusions Following fetal myelomeningocele repair, brain volume, shape and SI were significantly different from normal in most cerebral layers. Morphological brain changes after fetal surgery are not limited to hindbrain herniation reversal. These findings may have neurocognitive outcome implications and require further evaluation.