FMRI and intra-cranial electrocorticography recordings in the same human subjects reveals negative BOLD signal coupled with silenced neuronal activity

Positive blood oxygenation level-dependent (BOLD) responses (PBR), as measured by functional Magnetic Resonance Imaging (fMRI), are the most utilized measurements to non-invasively map activity in the brain. Recent studies have consistently shown that BOLD responses are not exclusively positive. Neg...

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Bibliographic Details
Published inBrain Structure and Function Vol. 227; no. 4; pp. 1371 - 1384
Main Authors Fracasso, Alessio, Gaglianese, Anna, Vansteensel, Mariska J., Aarnoutse, Erik J., Ramsey, Nick F., Dumoulin, Serge O., Petridou, Natalia
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2022
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Brain mapping
Brain Mapping - methods
Brain research
Cell Biology
Electrocorticography - methods
Electrodes
Electrophysiology
Functional magnetic resonance imaging
Human subjects
Humans
Magnetic Resonance Imaging - methods
Metabolism
Neuroimaging
Neurology
Neurosciences
Original
Original Article
Photic Stimulation
Research Subjects
Skull
Visual stimuli
Positive BOLD
Negative BOLD
Neuronal activity
ECoG
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Summary:Positive blood oxygenation level-dependent (BOLD) responses (PBR), as measured by functional Magnetic Resonance Imaging (fMRI), are the most utilized measurements to non-invasively map activity in the brain. Recent studies have consistently shown that BOLD responses are not exclusively positive. Negative BOLD responses (NBR) have been reported in response to specific sensory stimulations and tasks. However, the exact relationship between NBR and the underlying metabolic and neuronal demand is still under debate. In this study, we investigated the neurophysiological basis of negative BOLD using fMRI and intra-cranial electrophysiology (electrocorticography, ECoG) measurements from the same human participants. We show that, for those electrodes that responded to visual stimulation, PBR are correlated with high-frequency band (HFB) responses. Crucially, NBR were associated with an absence of HFB power responses and an unpredicted decrease in the alpha power responses.
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ISSN:1863-2653
1863-2661
1863-2661
0340-2061
DOI:10.1007/s00429-021-02342-4