The dual role of microRNA-9 in gastrointestinal cancers: oncomiR or tumor suppressor?

• Published in: Biomedicine & pharmacotherapy Vol. 145; p. 112394
• Main Authors: Bahrami, Afsane, Jafari, Amirsajad, Ferns, Gordon A.
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2022; Elsevier
• Subjects: CDX2; Cell Movement - genetics; Cell Proliferation - genetics; Colorectal cancer; CXCR-4; Cyclin D1; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - pathology; Gene Expression Regulation, Neoplastic; Humans; LncRNA; MicroRNAs - genetics; RNA Interference; RNA, Circular - genetics; RNA, Long Noncoding - genetics; Signal Transduction - genetics; LncRNA; CDX2; Cyclin D1; CXCR-4; Colorectal cancer
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2021.112394

microRNA are noncoding endogenous RNAs of ∼ 25-nucleotide, involved in RNA silencing and controlling of cell function. Recent evidence has highlighted the important role of various in the biology of human cancers. miR-9 is a highly conserved microRNA and abnormal regulation of miR-9 expression has various impacts on disease pathology. miR-9 may play a dual tumor-suppressive or oncomiR activity in several cancers. There have been conflicting reports concerning the role of miR-9 in gastrointestinal cancers. Several signaling pathways including PDK/AKT, Hippo, Wnt/β-catenin and PDGFRB axes are affected by miR-9 in suppressing proliferation, invasion and metastasis of tumor cells. Oncogenic miR-9 triggers migration, metastasis and clinic-pathological characteristics of patients with gastrointestinal malignancy by targeting various enzymes and transcription factors such as E-cadherin, HK2, LMX1A, and CDX2. On the other hand, long non-coding RNAs and circular RNAs can modulate miR-9 expression in human cancers. In this review, we aimed to summarize recent findings about the potential value of miR-9 in gastrointestinal tumors, that include: screening, prognostic and treatment. [Display omitted] •miR-9 play a dual tumor-suppressive or oncomir activity in gastrointestinal tumors.•mir-9 can act as an anti-tumor in gastric cancer by targeting RAB34 oncogene, cyclin D1, Ets1, CDX-2 and NF-κB1.•miR-9 act as a tumor suppressor by targeting molecules and pathways such as UHRF1, PAK4, CXCR4, FOXP2, TM4SF1, and ANO1.