Transcriptomic and neurochemical analysis of the stellate ganglia in mice highlights sex differences

The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of the nerves projecting to the heart has been observed in several cardiovascular diseases, however studies of adult stellate ganglia are limited. A profile of the baseline transcriptomic and neuroche...

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Bibliographic Details
Published inScientific reports Vol. 8; no. 1; pp. 8963 - 9
Main Authors Bayles, R. G., Olivas, A., Denfeld, Q., Woodward, W. R., Fei, S. S., Gao, L., Habecker, B. A.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 12.06.2018
Nature Publishing Group
Subjects
38
38/77
38/91
631/1647/2017
631/208/514/1949
631/337/2019
631/378/1959/1315
631/443/592
64/60
82/16
Animals
Brain Chemistry - physiology
Cardiovascular diseases
Female
Ganglia
Gender differences
Gene Expression Profiling
Gene Expression Regulation - physiology
Growth factors
High-performance liquid chromatography
Humanities and Social Sciences
Innervation
Ion channels
Liquid chromatography
Male
Mass spectrometry
Mass spectroscopy
Mice
multidisciplinary
Nerves
Rodents
Science
Science (multidisciplinary)
Sex Characteristics
Sex differences
Stellate ganglion
Stellate Ganglion - cytology
Stellate Ganglion - metabolism
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Summary:The stellate ganglia are the predominant source of sympathetic innervation to the heart. Remodeling of the nerves projecting to the heart has been observed in several cardiovascular diseases, however studies of adult stellate ganglia are limited. A profile of the baseline transcriptomic and neurochemical characteristics of the stellate ganglia in adult C57Bl6j mice, a common model for the study of cardiovascular diseases, may aid future investigations. We have generated a dataset of baseline measurements of mouse stellate ganglia using RNAseq, HPLC and mass spectrometry. Expression differences between male and female mice were identified. These differences included physiologically important genes for growth factors, receptors and ion channels. While the neurochemical profiles of male and female stellate ganglia were not different, minor differences in neurotransmitter content were identified in heart tissue.
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ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-27306-3