VEGF-A, sVEGFR-1, and sVEGFR-2 in BCR-ABL negative myeloproliferative neoplasms

• Published in: Medicina (Kaunas, Lithuania) Vol. 53; no. 1; pp. 34 - 39
• Main Authors: Gadomska, Grażyna, Stankowska, Katarzyna, Boinska, Joanna, Ślusarz, Robert, Tylicka, Marzena, Michalska, Małgorzata, Jachalska, Anna, Rość, Danuta
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier Sp. z o.o 2017; MDPI AG
• Subjects: Aged; BCR-ABL-negative myeloproliferative neoplasm; Blood Cell Count; Bone Marrow - blood supply; Bone Marrow - pathology; DNA Mutational Analysis; Female; Fibrinogen - analysis; Fusion Proteins, bcr-abl - genetics; Humans; Male; Middle Aged; Neovascularization, Pathologic - blood; Polycythemia Vera - diagnosis; Polycythemia Vera - genetics; Polycythemia Vera - physiopathology; Primary Myelofibrosis - diagnosis; Primary Myelofibrosis - genetics; Primary Myelofibrosis - physiopathology; Statistics, Nonparametric; sVEGFR-1; sVEGFR-2; Thrombocythemia, Essential - diagnosis; Thrombocythemia, Essential - genetics; Thrombocythemia, Essential - physiopathology; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor Receptor-1 - blood; Vascular Endothelial Growth Factor Receptor-2 - blood; VEGF-A; sVEGFR-2; sVEGFR-1; BCR-ABL-negative myeloproliferative neoplasm; VEGF-A
• ISSN: 1010-660X; 1648-9144
• DOI: 10.1016/j.medici.2017.01.004

Data from the literature indicate the relationship between the bone marrow microvessel density and the blood parameters of angiogenesis. The aim of this study was to evaluate selected parameters of angiogenesis (VEGF-A, sVEGFR-1, and sVEGFR-2) and their correlations with white blood cells, platelets, and red blood cells. The study included 72 patients (mean age, 61.84 years) with myeloproliferative neoplasms (MPNs): essential thrombocythemia (ET) (n=46), polycythemia vera (PV) (n=19), and primary myelofibrosis (PMF) (n=7). Serum VEGF-A, sVEGFR-1, and sVEGFR-2 were determined using the ELISA assay. We observed a significantly higher level of VEGF-A and reduced concentrations of sVEGFR-1 and sVEGFR-2 in the whole group of patients with MPNs as compared to controls. Detailed analysis confirmed significantly higher level of VEGF-A and lower concentration of sVEGFR-2 in each subgroups of MPNs patients. However, sVEGFR-1 concentrations were significantly lower only in PV and ET patients. The study showed an increased level of VEGF-A, which may indicate the intensity of neoangiogenesis in the bone marrow. Decreased sVEGFR-1 and sVEGFR-2 in the blood of patients with MPNs may reflect consumption of these soluble receptors.