Dynamic organization of mitotic chromosomes

Highlights • State-of-the-art technologies provide new insights into chromosome organization. • Mitotic chromatids can be reconstituted in vitro using only six purified factors. • HEAT subunits of condensin I are essential for chromosome axis assembly. • Mutations in condensin subunits cause microce...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 46; pp. 46 - 53
Main Authors Kinoshita, Kazuhisa, Hirano, Tatsuya
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2017
Subjects
Adenosine Triphosphatases - chemistry
Adenosine Triphosphatases - metabolism
Animals
Chromatids - chemistry
Chromatids - metabolism
Chromosomes - chemistry
Chromosomes - metabolism
DNA - chemistry
DNA - metabolism
DNA Topoisomerases, Type II - chemistry
DNA Topoisomerases, Type II - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Histones - chemistry
Histones - metabolism
Humans
Internal Medicine
Mitosis
Multiprotein Complexes - chemistry
Multiprotein Complexes - metabolism
Nucleosomes - chemistry
Nucleosomes - metabolism
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Summary:Highlights • State-of-the-art technologies provide new insights into chromosome organization. • Mitotic chromatids can be reconstituted in vitro using only six purified factors. • HEAT subunits of condensin I are essential for chromosome axis assembly. • Mutations in condensin subunits cause microcephaly and promote tumorigenesis. • Interphase TADs may be linked to cytological bands on mitotic chromosomes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/j.ceb.2017.01.006