Frozen-thawed embryo transfers: time to adopt a more “natural” approach?

• Published in: Journal of assisted reproduction and genetics Vol. 38; no. 8; pp. 1909 - 1911
• Main Authors: Pier, Bruce D., Havemann, Logan M., Quaas, Alexander M., Heitmann, Ryan J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2021; Springer Nature B.V
• Subjects: Adult; Birth rate; Commentary; Cryopreservation; Cryopreservation - standards; Embryo transfer; Embryo Transfer - methods; Embryos; Endocrinology; Endometrium; Endometrium - growth & development; Female; Gestational age; Gynecology; Hemorrhage; Human Genetics; Humans; In vitro fertilization; Infertility; Medicine; Medicine & Public Health; Menstruation; Ovaries; Ovulation; Patients; Polycystic ovary syndrome; Pregnancy; Pregnancy Rate; Reproductive health; Reproductive Medicine; Reproductive Techniques, Assisted - trends; Reproductive technologies; Systematic review; Womens health; In-vitro fertilization (IVF); Assisted reproductive technology (ART); Natural frozen-thawed embryo transfer; Frozen-thawed embryo transfer (FET)
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-021-02151-y

The increasing use of frozen–thawed embryo transfer (FET) cycles has magnified the focus on endometrial preparation protocols in assisted reproduction. Emerging evidence suggests that natural cycle (NC) FETs are associated with improved outcomes, and that providers should consider increasing the utilization of NC FET at the expense of the currently favored artificial cycle (AC) FET as primary method for endometrial preparation.