Effects of cadmium on antioxidant and non-specific immunity of Macrobrachium nipponense

• Published in: Ecotoxicology and environmental safety Vol. 224; p. 112651
• Main Authors: Wang, Long, Feng, Jianbin, Wang, Guiling, Guan, Tianyu, Zhu, Chuankun, Li, Jiale, Wang, Hui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2021; Elsevier
• Subjects: Antioxidant; Cadmium; Macrobrachium nipponense; Non-specific immunity; Cadmium; Macrobrachium nipponense; Antioxidant; Non-specific immunity
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2021.112651

As a non-essential and toxic element, cadmium poses an important threat to aquatic organisms and human food safety. In this study, the effects of cadmium on antioxidant and non-specific immunity of Macrobrachium nipponense were studied from the physiological and biochemical indexes, histology and expression of related genes. These results showed that low concentrations (0.01, 0.02 mg/L) of cadmium have a positive effect on the non-specific immunity of M. nipponense, but high concentration (0.04 mg/L) of cadmium could inhibit or even damage the non-specific immunity of M. nipponense. The cadmium could induce oxidative stress in M. nipponense, and M. nipponense actived the antioxidant defense system to deal with oxidative stress, but high concentration (0.04 mg/L) of cadmium could inhibit the antioxidant defense system of M. nipponense, leading to oxidative damage, and may induce apoptosis in severe case. At the same time, the results of histology showed that cadmium can damage the structure of gill and hepatopancreas tissues of M. nipponense. This study provides theoretical data for evaluating the influences of heavy metal cadmium on M. nipponense and the toxic mechanism of heavy metal cadmium. •The effects of cadmium stress for 96 h on M. nipponense were evaluated.•Cadmium stress could induce oxidative stress.•0.01, 0.02 mg/L of cadmium has a positive effect on the non-specific immunity.•0.04 mg/L cadmium stress could induce oxidative damage and apoptosis.•Cadmium could damage the structure of gill and hepatopancreas of M. nipponense.