In vitro antioxidant, antimicrobial, cytotoxic potential of gold and silver nanoparticles prepared using Embelia ribes

• Published in: Natural product research Vol. 31; no. 4; pp. 465 - 468
• Main Authors: Dhayalan, Manikandan, Denison, Michael Immanuel Jesse, L, Anitha Jegadeeshwari, Krishnan, Kathiravan, N, Nagendra Gandhi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 16.02.2017; Taylor & Francis Ltd
• Subjects: Anti-Infective Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Antineoplastic Agents - pharmacology; Antioxidants - pharmacology; Assaying; Biotechnology; Cell lines; Chemists; Cytotoxicity; Embelia - metabolism; Embelia ribes; Fourier transforms; Gold; Gold - pharmacology; gold nanoparticles; Green synthesis; Humans; In vitro methods and tests; Infrared spectroscopy; MCF-7 Cells; Metal Nanoparticles; Nanoparticles; Plant Extracts - metabolism; Scavenging; seed extract; Seeds - metabolism; Silver; Silver - pharmacology; silver nanoparticles; Single-nucleotide polymorphism; Spectroscopy, Fourier Transform Infrared; Synthesis; Toxicity; Embelia ribes; Green synthesis; silver nanoparticles; gold nanoparticles; seed extract
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2016.1166499

In recent years, the green synthesis of gold (GNPs) and silver (SNPs) nanoparticles has gained great interest among chemists and researchers. The present study reports an eco-friendly, cost-effective, rapid and easy method for the synthesis of gold and silver nanoparticles using the seed extract of Embelia ribes (SEEr) as capping and reducing agent. The synthesised GNPs and SNPs were characterised using the following techniques: UV-vis spectroscopy, DLS, HR-TEM, FT-IR and XRD. The free radical scavenging potential of GNPs and SNPs was measured by DPPH assay and Phosphomolybdenum assay. Further, the antimicrobial activity against two micro-organisms were tested using disc diffusion method and cytotoxicity of GNPs and SNPs was determined against MCF-7 cell lines at different concentrations by MTT assay. Both the GNPs and SNPs prepared from E. ribes comparatively showed promising results thereby proving their clinical importance.