Association of metal exposure with arterial stiffness in Chinese adults

• Published in: Ecotoxicology and environmental safety Vol. 257; p. 114921
• Main Authors: Wan, Zhengce, Wu, Mingyang, Liu, Qing, Fan, Gaojie, Fang, Qing, Qin, Xiya, Zhang, Xukuan, Lv, Yongman, Wang, Youjie, Bi, Jianing, Song, Lulu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.06.2023; Elsevier
• Subjects: Adult; Ankle Brachial Index; Arterial stiffness; Brachial-ankle pulse wave velocity; China; Chinese adults; Cross-Sectional Studies; East Asian People; Environmental Exposure - adverse effects; Humans; Metal exposure; Metals - adverse effects; Pulse Wave Analysis; Risk Factors; Vascular Stiffness; China; Mn; Cd; baPWV; GLM; FBG; Al; Co; BP; Cr; Rb; Cs; HDL; SD; Cu; As; Pb; Zn; LDL; U; V; Chinese adults; Tl; Ni; Brachial-ankle pulse wave velocity; BMI; Fe; Ba; Hg; LOD; Arterial stiffness; GM; CI; Metal exposure; TC; CVD; Se; TG; WQS; MAP; Sr
• ISSN: 0147-6513; 1090-2414; 1090-2414
• DOI: 10.1016/j.ecoenv.2023.114921

Arterial stiffness is an important indicator of cardiovascular aging. However, studies assessing the association between metal exposure and arterial stiffness are limited. The aim of this study was to investigate the independent and joint associations of metal exposure with arterial stiffness. This cross-sectional study recruited 2982 Chinese adults from August 2018 to March 2019 in Wuhan, China. The concentrations of 20 urinary metals were determined using inductively coupled plasma mass spectrometer. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). We used generalized linear model (GLM) to estimate the association of single metal exposure with baPWV. We used weighted quantile sum (WQS) regression to estimate the association of metal mixture with baPWV. In GLM regression analysis, each doubling of urinary copper (Cu) and chromium (Cr) concentrations were associated with 6.48 (95 % CI: 2.51–10.45) cm/s and 3.78 (95 % CI: 0.42–7.14) cm/s increase in baPWV, respectively. In WQS regression analysis, each unit increase in WQS index of the metal mixture was associated with a 9.10 (95 % CI: 2.39–15.82) cm/s increase in baPWV. Cu, Zn, and Cr were the dominant urinary metals associated with baPWV. Metal exposure, both individually and in mixture, was associated with an increased risk of arterial stiffness. Our findings may provide a target for preventative strategies against cardiovascular aging. [Display omitted] •Exposure to copper and chromium were related to higher risk of arterial stiffness.•Metal mixture exposure was associated with an increased risk of arterial stiffness.•Copper, zinc, and chromium contributed the most in metal mixture.