Purinergic modulation of the immune response to infections

Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi, bacteria, viruses, and parasites. After infection, disease progression relies on the complex interplay between the host immune response and the microorganism evasion strategies. The host’s survival depends on...

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Bibliographic Details
Published inPurinergic signalling Vol. 18; no. 1; pp. 93 - 113
Main Authors Eberhardt, Natalia, Bergero, Gastón, Mazzocco Mariotta, Yanina L., Aoki, M. Pilar
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2022
Springer Nature B.V
Subjects
Adaptive immunity
Biomedical and Life Sciences
Biomedicine
Cancer Research
Host-parasite interactions
Human Physiology
Immune clearance
Immune response
Immunomodulation
Infectious diseases
Inflammation
Microorganisms
Neurosciences
Pharmacology/Toxicology
Review
Review Article
Viral infections
Purinergic system
Adenosine
Infectious diseases
Immune response
ATP
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Summary:Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi, bacteria, viruses, and parasites. After infection, disease progression relies on the complex interplay between the host immune response and the microorganism evasion strategies. The host’s survival depends on its ability to mount an efficient protective anti-microbial response to accomplish pathogen clearance while simultaneously preventing tissue injury by keeping under control the excessive inflammatory process. The purinergic system has the dual function of regulating the immune response and triggering effector antimicrobial mechanisms. This review provides an overview of the current knowledge of the modulation of innate and adaptive immunity driven by the purinergic system during parasitic, bacterial and viral infections.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1573-9538
1573-9546
DOI:10.1007/s11302-021-09838-y