Selected protein expression in a new prognostic model for patients with non-muscle-invasive bladder cancer

• Published in: Journal of cancer research and clinical oncology Vol. 146; no. 8; pp. 2099 - 2108
• Main Authors: Semeniuk-Wojtaś, Aleksandra, Lubas, Arkadiusz, Cierniak, Szczepan, Brzóskowska, Urszula, Syryło, Tomasz, Zieliński, Henryk, Stec, Rafał
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020; Springer Nature B.V
• Subjects: Bacillus Calmette-Guerin vaccine; BCG; Bladder cancer; Cancer; Cancer Research; Decision Support Systems, Clinical; Disease-Free Survival; Female; Hematology; Humans; Immunohistochemistry; Immunotherapy; Internal Medicine; Invasiveness; Ki-67 Antigen - biosynthesis; Male; Medicine; Medicine & Public Health; Models, Statistical; Neoplasm Invasiveness; Neoplasm Recurrence, Local - metabolism; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Oncology; Original Article – Clinical Oncology; Original – Clinical Oncology; p53 Protein; Prognosis; Proportional Hazards Models; Retrospective Studies; Survivin; Survivin - biosynthesis; Tumor Suppressor Protein p53 - biosynthesis; Urinary Bladder Neoplasms - metabolism; Urinary Bladder Neoplasms - pathology; Urinary Bladder Neoplasms - surgery; Ki-67; NMIBC; Surviving; RECINT model; Bladder cancer; p53
• ISSN: 0171-5216; 1432-1335; 1432-1335
• DOI: 10.1007/s00432-020-03202-0

Introduction After transurethral resection of a bladder tumor, patients frequently have a recurrence of the disease, thereby requiring adjuvant therapy. Purpose The study aimed to determine the prognostic value of expression levels of p53, Ki-67, and survivin, and to develop a new prognostic model for patients with non-muscle-invasive bladder cancer (NMIBC) after transurethral resection of a bladder tumor. Methods The study group consisted of 101 patients with primary NMIBC. Univariate followed by multivariate Cox proportional hazard regression analysis was performed to obtain a model including the smallest possible number of descriptive variables with the highest statistical significance and impact on risk. Results The RECINT model (RECurrence In Not Treated) including factors independently associated with cancer recurrence (tumor size [HR 1.148; p  = 0.034], intensity of the color reaction for p53 [HR 1.716; p  = 0.008], Ki-67 [HR 3.001; p  = 0.022], and survivin [HR 1.461; p  = 0.021]) adequately stratified recurrence free-survival ( R 2  = 0.341, p < 0.001) in patients with primary NMIBC. Patients with the lowest RECINT score (0–6) had the lowest probability of cancer recurrence (1- and 5-year recurrence of 16%) in comparison with other groups ( p  < 0.001). Conclusions The RECINT model may be useful for stratifying the risk of recurrence in patients with non-muscle-invasive bladder cancer and may allow for identification of those who may benefit the most from adjuvant BCG immunotherapy.