Synergistic use of florfenicol and Salvia miltiorrhiza polysaccharide can enhance immune responses in broilers

• Published in: Ecotoxicology and environmental safety Vol. 210; p. 111825
• Main Authors: Han, Chao, Wang, Xiao, Zhang, Di, Wei, Yuanyuan, Cui, Yuqing, Shi, Wanyu, Bao, Yongzhan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.03.2021; Elsevier
• Subjects: Animal Feed; Animals; Anti-Bacterial Agents - pharmacology; Antibodies, Viral - blood; Broilers; Chickens - blood; Chickens - growth & development; Chickens - immunology; Cytokines - blood; Diet; Dietary Supplements; Florfenicol; Humans; Immune response; Immunity - drug effects; Immunoglobulins - blood; Influenza, Human - immunology; Leukocytes - drug effects; Newcastle disease virus - immunology; Polysaccharides - pharmacology; Salvia miltiorrhiza; Salvia Miltiorrhiza polysaccharide; Thiamphenicol - analogs & derivatives; Thiamphenicol - pharmacology; Salvia Miltiorrhiza polysaccharide; Immune response; Broilers; Florfenicol
• ISSN: 0147-6513; 1090-2414
• DOI: 10.1016/j.ecoenv.2020.111825

To explore the effect of florfenicol (FFC) combined with Salvia miltiorrhiza polysaccharide (SMPs) on immune function of Broilers. One hundred and twenty-one-day-old chicks were chosen and divided into 6 groups. The group A received standard basal diet only, the group B received a basal diet with FFC (0.15 g/L diet), and the group C, D, E received a basal diet with FFC (0.15 g/L diet) and SMPs (1.25 g/L, 2.5 g/L, 5 g/L diet)，the group F received a basal diet with SMPs (5 g/L diet). FFC can significantly inhibit the growth performance of broilers, but has no significant damage to the immune function of broilers. The combination of FFC and SMPs can improve the growth performance of broilers, increase the number of leukocyte subtypes in blood (P < 0.05), increase the number of Newcastle disease (ND) and avian influenza (AI) antibodies in blood, the number of immunoglobulins, and the content of cytokines (P < 0.05). In addition, it significantly improve the lymphocyte conversion rate of broiler peripheral blood (P < 0.05). So that, synergistic use of FFC and SMPs can enhance immune responses in Broilers. •FFC can significantly inhibit the growth performance of broilers.•FFC hasn’t significant damage to the immune function of broilers.•The combination of FFC and SMPs can improve the growth performance of broilers.•The combination of FFC and SMPs increase the antibodies levels.