Positron annihilation localization by nanoscale magnetization

• Published in: Scientific reports Vol. 10; no. 1; p. 20262
• Main Authors: Gholami, Yaser H., Yuan, Hushan, Wilks, Moses Q., Josephson, Lee, El Fakhri, Georges, Normandin, Marc D., Kuncic, Zdenka
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.11.2020; Nature Publishing Group
• Subjects: 639/766/747; 639/925/352; 639/925/352/1060; 639/925/352/2733; 639/925/352/2734; Cancer; Diagnostic agents; Humanities and Social Sciences; Humans; Instrumentation; Iron oxides; Localization; Magnetic fields; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetite Nanoparticles - chemistry; Medical imaging; Medical research; multidisciplinary; Nanoparticles; Positron emission tomography; Positron-Emission Tomography - methods; Positrons; Science; Science (multidisciplinary); Sensors; Spatial discrimination; Tomography
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-76980-9

In positron emission tomography (PET), the finite range over which positrons travel before annihilating with an electron places a fundamental physical limit on the spatial resolution of PET images. After annihilation, the photon pair detected by the PET instrumentation is emitted from a location that is different from the positron-emitting source, resulting in image blurring. Here, we report on the localization of positron range, and hence annihilation quanta, by strong nanoscale magnetization of superparamagnetic iron oxide nanoparticles (SPIONs) in PET-MRI. We found that positron annihilations localize within a region of interest by up to 60% more when SPIONs are present (with [Fe] = 3 mM) compared to when they are not. The resulting full width at half maximum of the PET scans showed the spatial resolution improved by up to ≈  30%. We also found evidence suggesting that the radiolabeled SPIONs produced up to a six-fold increase in ortho-positronium. These results may also have implications for emerging cancer theranostic strategies, where charged particles are used as therapeutic as well as diagnostic agents and improved dose localization within a tumor is a determinant of better treatment outcomes.