Rim lesions are demonstrated in early relapsing–remitting multiple sclerosis using 3 T-based susceptibility-weighted imaging in a multi-institutional setting

• Published in: Neuroradiology Vol. 64; no. 1; pp. 109 - 117
• Main Authors: Ng Kee Kwong, Koy Chong, Mollison, Daisy, Meijboom, Rozanna, York, Elizabeth N., Kampaite, Agniete, Martin, Sarah-Jane, Hunt, David P. J., Thrippleton, Michael J., Chandran, Siddharthan, Waldman, Adam D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022; Springer Nature B.V
• Subjects: Biomarkers; Brain - diagnostic imaging; Demyelination; Diagnostic Neuroradiology; Echo-Planar Imaging; Humans; Imaging; Inflammation; Lesions; Magnetic Resonance Imaging; Medical imaging; Medicine; Medicine & Public Health; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Radiology; Volumetric analysis; Susceptibility-weighted imaging; Multiple sclerosis; Rim lesions; Magnetic resonance imaging
• ISSN: 0028-3940; 1432-1920; 1432-1920
• DOI: 10.1007/s00234-021-02768-x

Purpose Rim lesions, characterised by a paramagnetic rim on susceptibility-based MRI, have been suggested to reflect chronic inflammatory demyelination in multiple sclerosis (MS) patients. Here, we assess, through susceptibility-weighted imaging (SWI), the prevalence, longitudinal volume evolution and clinical associations of rim lesions in subjects with early relapsing–remitting MS (RRMS). Methods Subjects ( n  = 44) with recently diagnosed RRMS underwent 3 T MRI at baseline (M0) and 1 year (M12) as part of a multi-centre study. SWI was acquired at M12 using a 3D segmented gradient-echo echo-planar imaging sequence. Rim lesions identified on SWI were manually segmented on FLAIR images at both time points for volumetric analysis. Results Twelve subjects (27%) had at least one rim lesion at M12. A linear mixed-effects model, with ‘subject’ as a random factor, revealed mixed evidence for the difference in longitudinal volume change between rim lesions and non-rim lesions ( p  = 0.0350 and p  = 0.0556 for subjects with and without rim lesions, respectively). All 25 rim lesions identified showed T1-weighted hypointense signal. Subjects with and without rim lesions did not differ significantly with respect to age, disease duration or clinical measures of disability ( p  > 0.05). Conclusion We demonstrate that rim lesions are detectable in early-stage RRMS on 3 T MRI across multiple centres, although their relationship to lesion enlargement is equivocal in this small cohort. Identification of SWI rims was subjective. Agreed criteria for defining rim lesions and their further validation as a biomarker of chronic inflammation are required for translation of SWI into routine MS clinical practice.