Full genome sequence of bovine alphaherpesvirus 2 (BoHV-2)

• Published in: Archives of virology Vol. 166; no. 2; pp. 639 - 643
• Main Authors: Pfaff, Florian, Neubauer-Juric, Antonie, Krebs, Stefan, Hauser, Andreas, Singer, Stefanie, Blum, Helmut, Hoffmann, Bernd
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.02.2021; Springer Nature B.V
• Subjects: Animals; Annotated Sequence Record; Base Composition - genetics; Biomedical and Life Sciences; Biomedicine; Cattle; Cattle Diseases - virology; DNA, Viral - genetics; Genome, Viral - genetics; Genomes; Herpesvirus 1, Bovine - genetics; Herpesvirus 2, Bovine - genetics; Infectious Diseases; Lumpy skin disease; Medical Microbiology; Nucleotide sequence; Open reading frames; Open Reading Frames - genetics; Phylogeny; Skin diseases; Virology
• ISSN: 0304-8608; 1432-8798
• DOI: 10.1007/s00705-020-04895-x

We present the complete genome sequence of bovine alphaherpesvirus 2 (BoHV-2), a member of the family Herpesviridae , subfamily Alphaherpesvirinae , genus Simplexvirus . BoHV-2 is the causative agent of bovine ulcerative mammillitis (bovine herpes mammillitis) and pseudo-lumpy skin disease. The genomic architecture of BoHV-2 is typical of most simplexvirus genomes and congruent with that of human alphaherpesvirus 1 (HHV-1). The genome comprises a total of 131,245 base pairs and has an overall G+C content of 64.9 mol%. A total of 75 open reading frames are predicted. The gene repertoire of BoHV-2 is analogous to that of HHV-1, although the coding region of US12 is missing. A phylogenetic analysis supported BoHV-2 as a member of the genus Simplexvirus .