Actomyosin ring driven cytokinesis in budding yeast

Cytokinesis is the final process in the cell cycle that physically divides one cell into two. In budding yeast, cytokinesis is driven by a contractile actomyosin ring (AMR) and the simultaneous formation of a primary septum, which serves as template for cell wall deposition. AMR assembly, constricti...

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Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 53; pp. 19 - 27
Main Authors Meitinger, Franz, Palani, Saravanan
Format Journal Article
LanguageEnglish
Published England Academic Press 01.05.2016
Subjects
Actomyosin - metabolism
Cytokinesis
Models, Biological
Review
Saccharomycetales - cytology
Saccharomycetales - metabolism
Saccharomycetales - ultrastructure
Cell division
Budding yeast
Cytokinesis
Actomyosin-ring
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Summary:Cytokinesis is the final process in the cell cycle that physically divides one cell into two. In budding yeast, cytokinesis is driven by a contractile actomyosin ring (AMR) and the simultaneous formation of a primary septum, which serves as template for cell wall deposition. AMR assembly, constriction, primary septum formation and cell wall deposition are successive processes and tightly coupled to cell cycle progression to ensure the correct distribution of genetic material and cell organelles among the two rising cells prior to cell division. The role of the AMR in cytokinesis and the molecular mechanisms that drive AMR constriction and septation are the focus of current research. This review summarizes the recent progresses in our understanding of how budding yeast cells orchestrate the multitude of molecular mechanisms that control AMR driven cytokinesis in a spatio-temporal manner to achieve an error free cell division.
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ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2016.01.043