Kaleidoscopic presentation of neurobrucellosis

Abstract Brucellosis remains an important public health problem especially in the underdeveloped countries as well as the Middle East. It may be a “master mimic” leading on to grave diagnostic dilemmas. Chronic neurobrucellosis is seldom associated with signs and symptoms of toxaemia due to multi or...

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Published inJournal of the neurological sciences Vol. 331; no. 1; pp. 165 - 167
Main Authors Kesav, Praveen, Modi, Manish, Singla, Veenu, Khurana, Dheeraj, Prabhakar, Sudesh
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.08.2013
Subjects
Abdomen - pathology
Antibiotics
Antimitotic Agents - therapeutic use
Brucellosis - complications
Brucellosis - diagnosis
Brucellosis - drug therapy
Central Nervous System Bacterial Infections - complications
Central Nervous System Bacterial Infections - diagnosis
Central Nervous System Bacterial Infections - drug therapy
Hearing Loss - drug therapy
Hearing Loss - etiology
Humans
Infections
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Male
Middle East
Neurobrucellosis
Neurology
Neuropathies
Sensorineural hearing loss
Tomography, X-Ray Computed
Toxemia
Young Adult
Middle East
Neurobrucellosis
Toxemia
Infections
Neuropathies
Sensorineural hearing loss
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Summary:Abstract Brucellosis remains an important public health problem especially in the underdeveloped countries as well as the Middle East. It may be a “master mimic” leading on to grave diagnostic dilemmas. Chronic neurobrucellosis is seldom associated with signs and symptoms of toxaemia due to multi organ dysfunction. We report the case of a 23-year-old man who presented with fever of 8 weeks associated with ascending weakness of lower limbs and sensorineural type of hearing loss of 6 weeks duration with prominent systemic findings in the form of hepatosplenomegaly and significant loss of weight. He responded well to treatment with combination antimicrobials with clinicoradiological resolution after 6 months of therapy. Even though a rare complication of brucellosis, neurobrucellosis causes significant morbidity if not promptly recognised and treated. Favourable outcomes can be achieved in neurobrucellosis with appropriate protracted polymicrobial antibiotic therapy as was illustrated in our patient.
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ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2013.05.026