Pharmacogenomic assessment of herbal drugs in affective disorders

• Published in: Biomedicine & pharmacotherapy Vol. 109; pp. 1148 - 1162
• Main Authors: Sahoo, Swati, S., Brijesh
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.01.2019; Elsevier
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; Anti-Anxiety Agents - therapeutic use; Anxiety; Anxiety - drug therapy; Anxiety - genetics; Depression; Gene/protein expression; Herbal drugs; Herbal Medicine - methods; Humans; Metabolomics; Mood Disorders - drug therapy; Mood Disorders - genetics; Pharmacogenetics - methods; Pharmacogenomics; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plants, Medicinal - chemistry; Metabolomics; CNTF; trkB; Gene/protein expression; OLE; CRH-R1; AP-1; SZS; 1H-MRS; PNS; NPY; Hspb8; GREs; Anxiety; Bet1l; CA; Pharmacogenomics; SJW; BST; IMI; MR; EST; Egr-1; Depression; IEG; IGF-1; Lut; NGF; PEA; Src-1; RA; GDNF; Ampd2; JuA; Herbal drugs; GPC; Hpcal1
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2018.10.135

[Display omitted] •Affective disorders like anxiety and depression are affecting a large population.•There is an increase in demand for herbal medicines for affective disorders.•Herbal drugs are facing acceptance issues due to lack of scientific evidence.•Omic technologies provide a platform for thorough evaluation of herbal drugs. Anxiety and depression, the most prevalent psychiatric disorders are co-morbid in nature affecting several people across the world. There is an increase in demand for complementary and alternative medicines, specifically herbal botanicals due to various side effects exhibited by conventional drugs. Herbal drugs mentioned in traditional medicines, face acceptance issues by the medical community due to lack of scientific data regarding their neurochemical pathways. Hence, there has been an increased interest in the quest to unravel the mechanisms of action of herbal psychotropics. With the advancements in “omic technologies” such as genomics, proteomics and metabolomics, research in the field of herbal psychopharmacology has gained momentum, providing a faster and informative platform for thorough evaluation of herbal drugs and formulations. In this article, we have reviewed several medicinal plants and their formulations that have shown potential anxiolytic and anti-depressant activities and have been screened for their biological mechanisms either at the gene, protein or metabolic level.