Pancreatic β-cell function relates positively to HDL functionality in well-controlled Type 2 diabetes mellitus

• Published in: Atherosclerosis Vol. 222; no. 2; pp. 567 - 573
• Main Authors: Dullaart, Robin P.F, Annema, Wijtske, de Boer, Jan Freark, Tietge, Uwe J.F
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ireland Ltd 01.06.2012; Elsevier
• Subjects: Adult; Aged; Analysis of Variance; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Blood Glucose - drug effects; Blood Glucose - metabolism; Cardiology. Vascular system; Cardiovascular; Cells, Cultured; Cellular cholesterol efflux; Chi-Square Distribution; Cholesterol - blood; Cholesterol efflux; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Fibroblasts - metabolism; Glycated Hemoglobin A - metabolism; HDL antioxidative function; High density lipoproteins; Homeostasis; Homeostasis model assessment; Humans; Hypoglycemic Agents - therapeutic use; Insulin - blood; Insulin sensitivity; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Linear Models; Lipoproteins, HDL - blood; Male; Medical sciences; Middle Aged; Netherlands; Oxidation-Reduction; Type 2 diabetes mellitus; β-Cell function; HDL antioxidative function; High density lipoproteins; Cellular cholesterol efflux; Insulin sensitivity; β-Cell function; Type 2 diabetes mellitus; Homeostasis model assessment; Cholesterol efflux; Endocrinopathy; Type 2 diabetes; Pancreatic hormone; Controlled diabetes; Homeostasis; Lipids; Metabolic diseases; Cardiovascular disease; Insulin; Cholesterol; Vascular disease; Atherosclerosis; β Cell; Lipoprotein HDL; Pancreas
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2012.03.037

Highlights ► Abnormalities in HDL functionality may affect β-cell function. ► HDL functionality was assessed as its anti-oxidative capacity and cholesterol efflux to plasma. ► β-cell function was related to these HDL functionality measures in well-controlled Type 2 diabetes. ► Such relationships were not observed in subjects with normal and impaired fasting glucose. ► Better HDL functionality may contribute to maintenance of β-cell function in Type 2 diabetes.