All around suboptimal health — a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine

• Published in: The EPMA journal Vol. 12; no. 4; pp. 403 - 433
• Main Authors: Wang, Wei, Yan, Yuxiang, Guo, Zheng, Hou, Haifeng, Garcia, Monique, Tan, Xuerui, Anto, Enoch Odame, Mahara, Gehendra, Zheng, Yulu, Li, Bo, Kang, Timothy, Zhong, Zhaohua, Wang, Youxin, Guo, Xiuhua, Golubnitschaja, Olga
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2021; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; COVID-19; Medicine/Public Health; Parametric statistics; Precision medicine; Prostate cancer; Adolescence; Epidemics; Pandemics; Body mass index (BMI); Cardiovascular disease; Traditional medicine; Communicable; Medical ethics; Behavioural patterns; COVID-19; Health policy; Dietary habits; Modifiable preventable risks; Risk assessment; Omics; Cancers; Neurologic diseases; Mood disorders; Liquid biopsy; Lifestyle; Periodontal health; Predictive preventive personalised medicine (PPPM/3PM); Stress overload; Big data management; Glycan; Individualised patient profile; Non-communicable diseases; Artificial intelligence (AI); Health economy; Natural substances; Multi-level diagnostics; Sleep medicine; Suboptimal health status (SHS); Multi-parametric analysis; Microbiome
• ISSN: 1878-5077; 1878-5085
• DOI: 10.1007/s13167-021-00253-2

First two decades of the twenty-first century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The time-frame between onset of SHS and clinical manifestation of associated disorders is the operational area for an application of reliable risk assessment tools and predictive diagnostics followed by the cost-effective targeted prevention and treatments tailored to the person. This article demonstrates advanced strategies in bio/medical sciences and healthcare focused on suboptimal health conditions in the frame-work of Predictive, Preventive and Personalised Medicine (3PM/PPPM). Potential benefits in healthcare systems and for society at large include but are not restricted to an improved life-quality of major populations and socio-economical groups, advanced professionalism of healthcare-givers and sustainable healthcare economy. Amongst others, following medical areas are proposed to strongly benefit from PPPM strategies applied to the identification and treatment of suboptimal health conditions: Stress overload associated pathologies Male and female health Planned pregnancies Periodontal health Eye disorders Inflammatory disorders, wound healing and pain management with associated complications Metabolic disorders and suboptimal body weight Cardiovascular pathologies Cancers Stroke, particularly of unknown aetiology and in young individuals Sleep medicine Sports medicine Improved individual outcomes under pandemic conditions such as COVID-19.