Carbohydrate based meningococcal vaccines: past and present overview

Neisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12  N. meningitidis serogroups are differentiated. Six of them...

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Bibliographic Details
Published inGlycoconjugate journal Vol. 38; no. 4; pp. 401 - 409
Main Authors Berti, Francesco, Romano, Maria Rosaria, Micoli, Francesca, Adamo, Roberto
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2021
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Glycoconjugate vaccines: classic and novel approaches
Glycoconjugates - chemistry
Humans
Life Sciences
Meningococcal Infections - microbiology
Meningococcal Infections - prevention & control
Meningococcal Vaccines - immunology
Mini Review
Neisseria meningitidis - classification
Neisseria meningitidis - immunology
Pathology
Polysaccharides
Reviews
Vaccines
Vaccines, Conjugate - immunology
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Summary:Neisseria meningitidis is a major cause of bacterial meningitidis worldwide. Children less than five years and adolescents are particularly affected. Nearly all invasive strains are surrounded by a polysaccharide capsule, based on which, 12  N. meningitidis serogroups are differentiated. Six of them, A, B, C, W, X, and Y, cause the vast majority of infections in humans. Mono- and multi-valent carbohydrate-based vaccines against meningococcal infections have been licensed or are currently in clinical development. In this mini-review, an overview of the past and present approaches for producing meningococcal glycoconjugate vaccines is provided.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0282-0080
1573-4986
DOI:10.1007/s10719-021-09990-y