Boundary functions in the control of gene expression

Recent experiments using stably transformed genes in mouse and Drosophila have demonstrated that elimination of euchromatic position effects can be used as a functional assay for domain boundaries. These studies will lead to an analysis of boundary structure, and in addition will provide clues to th...

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Bibliographic Details
Published inTrends in Genetics Vol. 7; no. 10; pp. 335 - 340
Main Authors Eissenberg, J.C., Elgin, S.C.R.
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1991
Subjects
Animals
Enhancer Elements, Genetic
Gene Expression Regulation
Promoter Regions, Genetic
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Summary:Recent experiments using stably transformed genes in mouse and Drosophila have demonstrated that elimination of euchromatic position effects can be used as a functional assay for domain boundaries. These studies will lead to an analysis of boundary structure, and in addition will provide clues to the mechanism(s) of gene regulation by higher order chromatin packaging.
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ObjectType-Review-1
ISSN:0168-9525
DOI:10.1016/0168-9525(91)90424-O