Podocyte-derived microparticles in IgA nephropathy

Microparticles are a general term for different types of cell plasma membrane-originated vesicles that are released into the extracellular environment. The paracrine action of these nano-sized vesicles is crucial for intercellular communications through the transfer of diverse lipids, cytosolic prot...

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Published inBiomedicine & pharmacotherapy Vol. 141; p. 111891
Main Authors Farzamikia, Negin, Baradaran, Behzad, Mostafavi, Soroush, Ahmadian, Elham, Hosseiniyan Khatibi, Seyed Mahdi, Zununi Vahed, Sepideh, Ardalan, Mohammadreza
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.09.2021
Elsevier
Subjects
Animals
Cytoplasmic Vesicles - pathology
Ectosome
Glomerulonephritis, IGA - pathology
Humans
IgA nephropathy
Microparticle
MicroRNAs
Microvesicle
Nanoparticles
Podocyte
Podocytes - pathology
Podocyte
Microparticle
Ectosome
IgA nephropathy
Microvesicle
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Summary:Microparticles are a general term for different types of cell plasma membrane-originated vesicles that are released into the extracellular environment. The paracrine action of these nano-sized vesicles is crucial for intercellular communications through the transfer of diverse lipids, cytosolic proteins, RNA as well as microRNAs. The progression of different diseases influences the composition, occurrence, and functions of these cell-derived particles. Podocyte injury has been shown to have an important role in the pathophysiology of many glomerular diseases including IgA nephropathy (IgAN). This review would focus on the possible potential of podocyte-derived microparticles detected in urine to be used as a diagnostic tool in IgAN.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2021.111891