Decorated graphene oxide with gold nanoparticles as a sensitive modified carbon paste electrode for simultaneous determination of tyrosine and uric acid

• Published in: Scientific reports Vol. 13; no. 1; p. 17501
• Main Authors: Garazhian, Elahe, Kalate Bojdi, Majid, Behbahani, Mohammad
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 15.10.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Amino acids; Blood pressure; Carbon; Electrochemistry; Electrodes; Electrons; Graphene; Kidney diseases; Light scattering; Microscopes; Nanomaterials; Nanoparticles; Oxidation; Phenylketonuria; Reproducibility; Spectroscopy; Tyrosine; Uric acid; Urine; Voltammetry; X-ray diffraction; Zeta potential
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-44540-6

Abstract It is presented here as a simple, selective, rapid, low-cost, with a wide linear range method to simultaneously determine tyrosine and uric acid using a modified carbon paste electrode decorated with graphene oxide and gold nanoparticles (GO/AuNPs/MCPE). In order to characterize and evaluate the morphology and constituents of the nanostructures, X-ray diffraction spectroscopy, Transmission electron microscopes, Dynamic light scattering, Zeta potential, electrochemical impedance spectroscopy, and Voltammetry were employed. The current response on the surface of the modified electrode had a dynamic linear range relationship in the concentrations of 0.14–340.00 µmol L −1 and 0.06–141.00 µmol L −1 for tyrosine and uric acid, respectively, and the method detection limit (MDL) was 0.0060 µmol L −1 and 0.0037 µmol L −1 , respectively. This modified electrode provided high stability, sensitivity, and acceptable reproducibility for voltammetric measurements of tyrosine and uric acid simultaneously in a biological matrix.