Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG

• Published in: Clinical cancer research Vol. 25; no. 8; pp. 2664 - 2671
• Main Authors: Raut, Chandrajit P, Callegaro, Dario, Miceli, Rosalba, Barretta, Francesco, Rutkowski, Piotr, Blay, Jean-Yves, Lahat, Guy, Strauss, Dirk C, Gonzalez, Ricardo, Ahuja, Nita, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, De Paoli, Antonino, Pillarisetty, Venu G, Nessim, Carolyn, Swallow, Carol J, Bagaria, Sanjay, Canter, Robert, Mullen, John, Gelderblom, Hans J, Pennacchioli, Elisabetta, van Coevorden, Frits, Cardona, Kenneth, Fiore, Marco, Fairweather, Mark, Gronchi, Alessandro
• Format: Journal Article
• Language: English
• Published: United States 15.04.2019
• Subjects: Aged; Combined Modality Therapy; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Nomograms; Prognosis; Retroperitoneal Neoplasms - mortality; Retroperitoneal Neoplasms - pathology; Retroperitoneal Neoplasms - surgery; Retroperitoneal Neoplasms - therapy; Sarcoma - mortality; Sarcoma - pathology; Sarcoma - surgery; Sarcoma - therapy; Treatment Outcome
• ISSN: 1078-0432; 1557-3265
• DOI: 10.1158/1078-0432.ccr-18-2700

The role of surgery for first relapse locally recurrent retroperitoneal sarcoma (RPS-LR1) is uncertain. We report outcomes of the largest RPS-LR1 series and propose a new prognostic nomogram. Patients with consecutive RPS-LR1 without distant metastases who underwent resection at 22 centers (2002-2011) were included. Endpoints were disease-free and overall survival (DFS, OS) and crude-cumulative-incidence (CCI) of local/distant recurrence from second surgery. Nomograms predicting DFS and OS from second surgery were developed and validated (calibration plots); discrimination was assessed (Harrell C index). Of 684 patients identified, full prognostic variable data were available for 602. Initial surgery for primary RPS was performed at our institutions in 188 patients (31%) and elsewhere in 414 (69%). At a median follow-up of 119 months [Interquartile range (IQR), 80-169] from initial surgery and 75 months (IQR 50-105) from second surgery, 6-year DFS and OS were 19.2% [95% confidence interval (CI), 16.0-23.0%] and 54.1% (95% CI, 49.8-58.8%), respectively. Recurrence patterns and survival probability were histology-specific, with liposarcoma subtypes having the highest 6-year CCI of second local recurrence (LR, 60.2%-70.9%) and leiomyosarcoma (LMS) having higher 6-year CCI of distant metastasis (DM, 36.3%). Nomograms included age at second surgery, multifocality, grade, completeness of second surgery, histology, chemotherapy/radiotherapy at first surgery, and number of organs resected at first surgery. OS and DFS nomograms showed good calibration and discriminative ability (C index 0.70 and 0.67, respectively). We developed nomograms to predict DFS and OS for patients undergoing RPS-LR1 resection. Nomograms provide individualized, disease-relevant estimations of survival for RPS-LR1 patients and assist in clinical decisions.