The effects of brominated flame retardants (BFRs) on pro-atherosclerosis mechanisms

Brominated flame-retardants (BFRs) are environmental endocrine disruptors, comprising several pollutants, which potentially affect the endocrine system and cause dysfunction and disease. Widespread BFR exposure may cause multisystem toxicity, including cardiovascular toxicity in some individuals. St...

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Published inEcotoxicology and environmental safety Vol. 262; p. 115325
Main Authors Wu, Hai-Di, Yang, Li-Wei, Deng, Da-Yong, Jiang, Rong-Na, Song, Zi-Kai, Zhou, Li-Ting
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.09.2023
Elsevier
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Summary:Brominated flame-retardants (BFRs) are environmental endocrine disruptors, comprising several pollutants, which potentially affect the endocrine system and cause dysfunction and disease. Widespread BFR exposure may cause multisystem toxicity, including cardiovascular toxicity in some individuals. Studies have shown that BFRs not only increase heart rate, induce arrhythmia and cardiac hypertrophy, but also cause glycolipid metabolism disorders, vascular endothelial dysfunction, and inflammatory responses, all of which potentially induce pre-pathological changes in atherosclerosis. Experimental data indicated that BFRs disrupt gene expression or signaling pathways, which cause vascular endothelial dysfunction, lipid metabolism-related disease, inflammation, and possibly atherosclerosis. Considerable evidence now suggests that BFR exposure may be a pro-atherosclerotic risk factor. In this study, we reviewed putative BFR effects underpinning pro-atherosclerosis mechanisms, and focused on vascular endothelial cell dysfunction, abnormal lipid metabolism, pro-inflammatory cytokine production and foam cell formation. Consequently, we proposed a scientific basis for preventing atherosclerosis by BFRs and provided concepts for further research. [Display omitted] •BFRs could induce pre-pathological changes in atherosclerosis.•BFRs cause vascular endothelial dysfunction, lipid metabolism-related disease and inflammation.•BFRs effects underpinning pro-atherosclerosis mechanisms.
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ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2023.115325