Review: Molecular mechanism of microglia stimulated glioblastoma invasion

• Published in: Matrix biology Vol. 32; no. 7-8; pp. 372 - 380
• Main Authors: Coniglio, Salvatore J., Segall, Jeffrey E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2013
• Subjects: CSF-1R; Cytokines - metabolism; Extracellular Matrix Proteins - metabolism; Glioblastoma - physiopathology; Glioma; Humans; Intercellular Signaling Peptides and Proteins - metabolism; Invasion; Macrophages; Macrophages - physiology; Microglia; Microglia - physiology; MMPs; Neoplasm Invasiveness - physiopathology; Paracrine Communication - physiology; Peptide Hydrolases - metabolism; Signal Transduction - physiology; TGFβ; Glioma; MMPs; TGFβ; Macrophages; Invasion; CSF-1R; Microglia
• ISSN: 0945-053X; 1569-1802; 1569-1802
• DOI: 10.1016/j.matbio.2013.07.008

Glioblastoma multiforme is one of the deadliest human cancers and is characterized by a high degree of microglia and macrophage infiltration. The role of these glioma infiltrating macrophages (GIMs) in disease progression has been the subject of recent investigation. While initially thought to reflect an immune response to the tumor, the balance of evidence clearly suggests GIMs can have potent tumor-tropic functions and assist in glioma cell growth and infiltration into normal brain. In this review, we focus on the evidence for GIMs aiding mediating glioblastoma motility and invasion. We survey the literature for molecular pathways that are involved in paracrine interaction between glioma cells and GIMs and assess which of these might serve as attractive targets for therapeutic intervention. •Microglia are necessary for glioma brain tumor progression.•Glioma tumor cells express factors which recruit and reprogram microglia for this purpose.•Glioma infiltrating microglia (GIMs) secrete a variety of soluble factors which promote glioma invasion.