Building silent compartments at the nuclear periphery: a recurrent theme

In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear peri...

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Bibliographic Details
Published inCurrent opinion in genetics & development Vol. 23; no. 2; pp. 96 - 103
Main Authors Meister, Peter, Taddei, Angela
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2013
Subjects
Animals
Caenorhabditis elegans - genetics
Cell Nucleus - genetics
Chromatin - genetics
Chromatin - metabolism
Gene Expression Regulation
Genomic Instability
Humans
Medical Education
Nuclear Envelope - genetics
Nuclear Envelope - metabolism
Nuclear Proteins - genetics
Saccharomyces cerevisiae - genetics
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Summary:In eukaryotes, the genetic material is stored in the nucleus, which is enclosed in a double lipid bilayer, the nuclear envelope (NE). It protects the genome from physical stress and separates it from the rest of the cell. On top of this physical function, growing evidence shows that the nuclear periphery contributes to the 3D organization of the genome. In turn, tridimensional organization of chromatin in the nuclear space influences genome expression. Here we review recent findings on the function of this physical barrier in gene repression and latest models on how silent subnuclear compartments at the NE are built in yeast as well as in the nematode C. elegans and mammalian cells; trying to draw parallels between the three systems.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2012.12.001