Energy metabolism: A critical target of cardiovascular injury

• Published in: Biomedicine & pharmacotherapy Vol. 165; p. 115271
• Main Authors: Li, Qiyang, Zhang, Shangzu, Yang, Gengqiang, Wang, Xin, Liu, Fuxian, Li, Yangyang, Chen, Yan, Zhou, Ting, Xie, Dingxiong, Liu, Yongqi, Zhang, Liying
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.09.2023; Elsevier
• Subjects: Diabetic cardiomyopathy; Energy metabolism; Heart failure; Ischemia/reperfusion injury; Ischemic heart disease; Mitochondrion; CHF; NADPH; IRI; MPC; Energy metabolism; HK; Ischemia/reperfusion injury; IHD; BCKA; BDK; FACS; Ischemic heart disease; LDH; PPP; PDH; HBP; MCT1; mTOR; Diabetic cardiomyopathy; CD36; MCAD; PCr; Heart failure; ACC; GLUT1; CK; SOD; AKT; FADH2; PGC-1α; PPARs; BCKDH; MCD; CVD; mtPTP; Mitochondrion; PFK-1; PFK-2; TCA; BDH1; BCATm; AMPK; GLUT4; BCAA; CPT-1
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2023.115271

Cardiovascular diseases are the main killers threatening human health. Many studies have shown that abnormal energy metabolism plays a key role in the occurrence and development of acute and chronic cardiovascular diseases. Regulating cardiac energy metabolism is a frontier topic in the treatment of cardiovascular diseases. However, we are not very clear about the choice of different substrates, the specific mechanism of energy metabolism participating in the course of cardiovascular disease, and how to develop appropriate drugs to regulate energy metabolism to treat cardiovascular disease. Therefore, this paper reviews how energy metabolism participates in cardiovascular pathophysiological processes and potential drugs aimed at interfering energy metabolism.It is expected to provide good suggestions for promoting the clinical prevention and treatment of cardiovascular diseases from the perspective of energy metabolism. [Display omitted] •Cardiovascular diseases are the main killers threatening human health.•Energy metabolism plays an important role in cardiac pathophysiology.•Modern drugs, natural products and traditional Chinese medicine formulas have the potential to regulate cardiac energy metabolism.•Targeted energy metabolism can delay the progress of cardiovascular diseases.