Assessment of Daily Replanning and Geometrical Variation of High-dose-rate Brachytherapy for the Prostate

• Published in: Anticancer research Vol. 40; no. 3; pp. 1677 - 1682
• Main Authors: Uchida, Hirofumi, Hirata, Takero, Otani, Keisuke, Suzuki, Osamu, Oda, Michio, Akino, Yuichi, Sumida, Iori, Hatano, Koji, Fujita, Kazutoshi, Uemura, Motohide, Imamura, Ryoichi, Eino, Daisuke, Yoshioka, Yasuo, Nonomura, Norio, Ogawa, Kazuhiko
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.03.2020
• Subjects: Aged; Brachytherapy; Brachytherapy - methods; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms - pathology; Prostatic Neoplasms - therapy; Radiation dosage; Radiation therapy; Radiotherapy Dosage; Rectum; Urethra; HDR-BT; brachytherapy; Prostate cancer; daily replanning
• ISSN: 0250-7005; 1791-7530
• DOI: 10.21873/anticanres.14119

The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning. This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018. Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose distributed to the highest irradiated rectal volume of 5 cc became significantly higher on day 2 (p=0.02), and the maximum dose distributed to the urethra became significantly higher on day 2 (p=0.01). Conformal, high-dose delivery of HDR-BT is impaired without replanning not only on the second day but also on the third day. Daily replanning is required for achieving accuracy of HDR-BT.