Glial Factors Regulating White Matter Development and Pathologies of the Cerebellum

• Published in: Neurochemical research Vol. 45; no. 3; pp. 643 - 655
• Main Authors: Revuelta, Miren, Scheuer, Till, Chew, Li-Jin, Schmitz, Thomas
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2020; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Central nervous system; Cerebellum; Cerebellum - pathology; Chemokines; Circuits; Cognition; Cytokines; Glial cells; Growth factors; Humans; Motor task performance; Neurochemistry; Neurodegenerative diseases; Neurodevelopmental disorders; Neuroglia - pathology; Neurology; Neuronal-glial interactions; Neurosciences; Neurotransmitters; Original Paper; Signal Transduction; Signs and symptoms; Substantia alba; Transcription factors; White Matter - pathology; Cerebellum; Development; Therapy; Glia; Pathologies
• ISSN: 0364-3190; 1573-6903
• DOI: 10.1007/s11064-020-02961-z

The cerebellum is a brain region that undergoes extremely dynamic growth during perinatal and postnatal development which is regulated by the proper interaction between glial cells and neurons with a complex concert of growth factors, chemokines, cytokines, neurotransmitters and transcriptions factors. The relevance of cerebellar functions for not only motor performance but also for cognition, emotion, memory and attention is increasingly being recognized and acknowledged. Since perturbed circuitry of cerebro-cerebellar trajectories can play a role in many central nervous system pathologies and thereby contribute to neurological symptoms in distinct neurodevelopmental and neurodegenerative diseases, is it the aim with this mini-review to highlight the pathways of glia–glia interplay being involved. The designs of future treatment strategies may hence be targeted to molecular pathways also playing a role in development and disease of the cerebellum.