Effect of sleeve gastrectomy on body weight, food intake, glucose tolerance, and metabolic hormone level in two different rat models: Goto-Kakizaki and diet-induced obese rat

• Published in: The Journal of surgical research Vol. 185; no. 1; pp. 159 - 165
• Main Authors: Trung, Vo Nguyen, MD, Yamamoto, Hiroshi, MD, PhD, Yamaguchi, Tsuyoshi, MD, PhD, Murata, Satoshi, MD, PhD, Akabori, Hiroya, MD, PhD, Ugi, Satoshi, MD, PhD, Maegawa, Hiroshi, MD, PhD, Tani, Tohru, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2013
• Subjects: Animals; Blood Glucose - metabolism; Body Weight - physiology; Diabetes; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - metabolism; Diet, High-Fat; Diet-induced obese rat; Disease Models, Animal; Eating - physiology; Gastrectomy - methods; Ghrelin - blood; Glucagon-Like Peptide 1 - blood; Glucose Intolerance - metabolism; Glucose Tolerance Test; Goto-Kakizaki rat; Hormones - blood; Insulin - blood; Male; Obesity - metabolism; Obesity - surgery; Rats; Rats, Mutant Strains; Rats, Wistar; Sleeve gastrectomy; Surgery; Goto-Kakizaki rat; Diabetes; Diet-induced obese rat; Sleeve gastrectomy
• ISSN: 0022-4804; 1095-8673
• DOI: 10.1016/j.jss.2013.05.019

Abstract Background It is still an important question whether sleeve gastrectomy (SG) is appropriate only in the context of obesity—the condition for which it was originally developed—or whether lean people with insulin-deficient diabetes might also benefit. The aim of this study is to evaluate the effects of SG in Goto-Kakizaki (GK) and diet-induced obese (DIO) rats that have distinct characteristics in beta-cell function and fat mass. Materials and methods SG was performed in GK and DIO rats. Body weight, food intake, and fasting blood glucose were monitored after surgery. Des-acyl ghrelin in fasting condition and blood glucose, insulin, and glucagon-like peptide-1 levels during meal test were measured. Homeostatic model assessment and insulinogenic index were examined. Results In both GK and DIO rats, SG improved glucose tolerance with increased glucagon-like peptide-1 and insulin secretion during meal test, and reduced fasting des-acyl ghrelin levels. Insulin sensitivity was enhanced after SG in DIO rats. The improvement in glucose tolerance after SG was shown earlier in DIO rats than in GK rats and weight regain after SG occurred faster and was more prominent in GK rats than in DIO rats. Conclusions In both DIO and GK rats, SG could improve glucose tolerance with increased insulin secretion and/or action. The improvement in glucose tolerance was shown earlier in DIO rats than in GK rats.